“The global economic and financial crisis has had some negative implications in Cameroon’s growth. Extrapolation of the growth impact leads to a deterioration in poverty and inequality indicators. Government finance, inflation, employment, current account balance, remittances have also been negatively affected by the global economic and financial crisis. The major objective of the paper is to analyse the impact of the global economic and financial crisis on Cameroon’s economy and propose some policy options aimed at minimizing the impact of the crisis. The paper is organized as follows. Section 2 presents Cameroon’s economy prior to the crisis. In section three, the impact of the global economic and financial crisis on the global economy is discussed while section four is centred on the impact of the crisis on Cameroon’s economy. Section five that outlines some policy implications stresses on government response to the global crisis as well as potential policy options. Section six concludes the paper. “