COVID-19 poses great risks to the African and global community but in what could otherwise be apocalyptic despair, there are also great opportunities to change the style and practice of international relations. Most crucially, there is now the normative and conceptual space for South Africa to engage in a serious review of the essential tenets and postulates of its foreign policy since there are critical lessons arising from COVID-19 with regard to how it can become a more caring country at home and a more responsible global citizen abroad.