Low- and middle-income countries (LMICs) ordinarily experience protracted epidemiological transitions – the dual burden of infection and chronic noncommunicable disease (NCD). The COVID-19 pandemic has left LMICs with a triple burden: pre-existent NCDs; infection responses; and a pandemic response financing gap. Addressing the burden will require strategic intervention and more finance. This briefing explores how governments and donors can navigate current global health challenges to adequately respond to the pandemic while sustainably mobilising resources to strengthen global health interventions in the long term.