The objective of this study was to analyse the nexus between youth unemployment and political instability in Côte d’Ivoire. To achieve this objective, we used a regional approach to investigate the relationship between political instability and youth unemployment in Côte d’Ivoire and we developed a method for calculating the political instability indicator. Analytical, descriptive and econometric methods were used to analyse data from surveys conducted in relation to household living standards levels and surveys on employment. The results indicate that, by considering only persons aged from 15 to 24 years as young people, one might underestimate youth unemployment and the impact of policies aimed at combating youth unemployment. The statistics also revealed a very high level of youth unemployment. The econometric estimation results equally showed a positive and significant relationship between youth unemployment and political instability.