Forced to adjust its relatively upbeat economic forecast issued earlier in 2020, the International Monetary Fund (IMF) declared that the world would enter a recession due to COVID-19. Despite lockdowns, curfews, and other measures to curb its spread, the number of infections has passed 73 million cases worldwide by mid-December 2020. In light of this unprecedented situation, “resilience’’ has probably been the most employed term in countries’ efforts to mitigate the COVID-19 impact and to rethink how countries of the South may rebuild their as well other economies and societies in the mid to long terms. As far as the COVID-19 health consequences are concerned, this working paper puts forward the notion of resilience and its incorporation into Agenda 2030 for Sustainable Development and Agenda 2063 ‘’the Africa We Want’’ and, more specifically, its link with SDG three – health and well-being. Second, it displays the role of APRM in building resilient institutions and sustainable communities in Africa under the South-South and Triangular Cooperation Framework. Lastly, it highlights partnerships that APRM has developed under the newly expanded mandate to address SSC challenges in Africa and operationalize resilient policies amongst African countries under the framework of Agenda 2063 and Sustainable Development Goals (SDGs).