South Sudan is experiencing a distressing economic period. Government revenue has shrunk to historic lows and debt, both domestic and external, is mounting, marked by unsettled salary arrears and outstanding loans. A combination of the COVID-19 pandemic and the fallout of just-concluded civil strife is largely to blame. The pandemic and conflict have dramatically impeded oil sales, collection of non-oil revenues, and access to remittances and foreign aid. While income levels have dropped drastically, the cost of basic commodities continues to spiral upward. The government initially introduced economically taxing COVID-19 restrictions before relaxing them four months later; other pandemic-related actions included cushioning the foreign exchange market, shaking-up the economic sector’s leadership, and attempting to abolish the South Sudanese pound. This review analyzes the economic impacts of the COVID-19 pandemic, and specifically focuses on production, the performance of the commodity and foreign exchange markets, and resultant government policy interventions.