Understanding the intricacies associated with optimal utilization of Africa’s agricultural potential and addressing the challenges preventing its expansion would increase production significantly. To do this, tangible investments in agricultural inputs, infrastructure, and market expansion are recommended. This investment is expected to open up the possibility of full participation from the pool of smallholder famers in Africa. A large chunk of Africa’s smallholder farmers will be induced into productive and commercial agriculture by this step. While the challenges are many, relatively low–investment opportunities exist to innovate on route-to-market approaches along the supply chain. Demand-side farmer engagement, public-private partnership with stakeholders in Agriculture, use of Internet of Things (IoT), integration of the Agriculture Blochian Technology alongside other ecosystem players, can help build markets to realize Africa’s significant potential.