Globalization has major linkages to the spread of diseases. This paper analyses the link between globalization and the COVID-19 pandemic and provides an overview of how Africa’s economy is being impacted by this new disease. It highlights the impacts on GDP growth and economic sectors. It provides recommendations of what should be done by African governments to address the problem. It concludes by calling on African governments to consider the socio-economic circumstances of their people when responding and mitigating the risk of COVID-19 and to carefully calculate and consider the risks posed via three main economic channels—demand,supply, and finance—which could have a serious impact on ordinary citizens in Africa.