As the world is faced with the unprecedented challenges from COVID-19, the strain on many governments is extreme, and the impact on people all over the world continues to grow. Indeed, the COVID-19 pandemic has disrupted the social and economic structures of service delivery with significant consequences on lives, livelihoods, and general economic development. As part of the response mechanism to contain and manage the COVID-19 pandemic, the Government of Uganda (GoU) instituted national and sub-national COVID-19 task forces to implement and manage the COVID-19 pandemic containment and recovery measures. The Presidential Decree on COVID-19 recognizes the Central Government’s role in the provision of healthcare and security. District Taskforces (DTFs) were put in place to support Central Government’s containment of COVID-19 and implementation of the GoU COVID-19 containment strategies of case management, surveillance, health promotion, resource mobilization, enforcement of standard operating procedures (SOPs) and continued delivery of basic services. This report is an important assessment of the performance of the DTFs in implementing the COVID-19 pandemic containment plan. The main objective of the study is to identify the determinants and level of performance of District Covid-19 Task Forces to enhance their effectiveness.