Urban flooding is threatening public health in affected communities in many ways. Therefore, it is of public interest to find effective strategies for building up resilience to human health in order to minimize the many potential adverse impacts while maximising potential health opportunities. The “Living with Water” project – combining flood infrastructure measures with adaptive and transformative processes of resilience-building – presents a unique opportunity to study whether an integrative approach to flood management and resilience-building allows to safeguard human health or even result in health benefits. Specifically, the health impact evaluation that was implemented along with the other research components, pursued the following research question in the given context: does improved infrastructure and resilience result in: (i) a reduction in fever and diarrhoea rates in children under the age of 5 years; (ii) improve access to health care; and (iii) improve mental wellbeing in the adult population?