The establishment of national commissions of inquiry is a common governmental response in the aftermath of crisis, including allegations of major human rights violations. Proponents of such commissions suggest that they are a more flexible, participatory and open mechanism to determine, in the first instance, ‘What happened?’ and ‘Who was affected?’, than immediate criminal investigation. The extent of the state’s obligations to investigate and to pursue accountability in the aftermath of a violation of human rights is being outlined in this policy brief – particularly in the case of a potential violation of the right to life. Drawing on the recently revised Minnesota Protocol on the Investigation of Potentially Unlawful Death (2016), as well as on a long-running research project on commissions of inquiry in Africa. The policy brief elaborates on some of the standards that could be used to establish whether a commission of inquiry is an appropriate mechanism for a particular context, and whether its establishment contributes to government fulfilling its obligation to conduct a prompt, impartial, thorough and transparent investigation.